It was estimated that for the year 2007 in the United States, there would be 213,380 new cases of lung cancer and 160,390 deaths. Lung cancer is the most common malignancy in the world and the leading cause of cancer death for both men and women. 85-90% of all lung cancers are non-small cell lung cancer (NSCLC).

While surgical lobectomy is considered standard of care for stage I NSCLC patients who can tolerate the procedure, sublobar resection or wedge resection is an alternative surgical option for high risk stage I NSCLC patients unable to tolerate lobectomy due to compromised physiologic reserve. 1

lung image area

4. Lung cancer page -Recent studies have demonstrated that the adjunct use of I-125 (polyglactin 910) absorbable mesh following sublobar resection for high-risk stage I NSCLC patients is a technically simple procedure requiring little additional operating room time and very low radiation exposure to staff. I-125 Lung Brachytherapy has been shown to significantly improve local recurrence rates: 19% with sublobar resection alone vs 2% with sublobar resection plus brachytherapy. Length of hospital stay and incidence of post-operative complication was similar compared to sublobar resection alone. The American College of Surgeons Oncology Group (ACOSOG) is conducting a randomized phase III study of sublobar resection versus sublobar resection plus brachytherapy in high-risk patients with non-small cell lung cancer (NSCLC) 3 cm or smaller (Protocol: Z4032). For more study information, please go to www.acosog.org.2

  1. Santos R, Colonias A, Parda D et al. Comparison between sublobar resection and 125iodine brachytherapy following sublobar resection in high-risk patients with stage I Non-small cell cancer. Surgery. 2003. 134(4):691-7
  2. https://www.acosog.org/studies/index.jsp (Protocol: Z4032)

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